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Mechanisms and impacts of chromosomal translocations in cancers
null
《医学前沿(英文)》 2012年 第6卷 第3期 页码 263-274 doi: 10.1007/s11684-012-0215-5
Chromosomal aberrations have been associated with cancer development since their discovery more than a hundred years ago. Chromosomal translocations, a type of particular structural changes involving heterologous chromosomes, have made a critical impact on diagnosis, prognosis and treatment of cancers. For example, the discovery of translocation between chromosomes 9 and 22 and the subsequent success of targeting the fusion product BCR-ABL transformed the therapy for chronic myelogenous leukemia. In the past few decades, tremendous progress has been achieved towards elucidating the mechanism causing chromosomal translocations. This review focuses on the basic mechanisms underlying the generation of chromosomal translocations. In particular, the contribution of frequency of DNA double strand breaks and spatial proximity of translocating loci is discussed.
关键词: DNA double strand breaks chromosomal translocations genomic instability spatial proximity carcinogenesis
A novel decoupling approach to an integrated optical-fiber proximity sensor for robots
LIU Guixiong, LI Xiani
《机械工程前沿(英文)》 2007年 第2卷 第2期 页码 164-167 doi: 10.1007/s11465-007-0027-5
关键词: multiscale different self-compensational integrated information implementation
Diffusion process in enzyme–metal hybrid catalysts
《化学科学与工程前沿(英文)》 2022年 第16卷 第6期 页码 921-929 doi: 10.1007/s11705-022-2144-4
关键词: enzyme–metal hybrid catalyst internal diffusion proximity effect kinetic model
Soil spatial variability impact on the behavior of a reinforced earth wall
Adam HAMROUNI, Daniel DIAS, Badreddine SBARTAI
《结构与土木工程前沿(英文)》 2020年 第14卷 第2期 页码 518-531 doi: 10.1007/s11709-020-0611-x
关键词: reinforced earth wall geosynthetic random field spatial variability Monte Carlo simulation
Industrial eco-efficiency and its spatial-temporal differentiation in China
Wei YANG, Fengjun JIN, Chengjin WANG, Chen LV
《环境科学与工程前沿(英文)》 2012年 第6卷 第4期 页码 559-568 doi: 10.1007/s11783-012-0400-4
关键词: industrial eco-efficiency data envelopment analysis (DEA) model exploratory spatial data analysis (ESDA)
Border-search and jump reduction method for size optimization of spatial truss structures
Babak DIZANGIAN, Mohammad Reza GHASEMI
《结构与土木工程前沿(英文)》 2019年 第13卷 第1期 页码 123-134 doi: 10.1007/s11709-018-0478-2
关键词: optimum design sensitivity analysis reduction method spatial trusses OpenSees
《环境科学与工程前沿(英文)》 2023年 第17卷 第10期 doi: 10.1007/s11783-023-1724-y
关键词: Microplastic Environmental transport Soil pollution Stormwater Detention ponds
Spatial prediction of soil contamination based on machine learning: a review
《环境科学与工程前沿(英文)》 2023年 第17卷 第8期 doi: 10.1007/s11783-023-1693-1
● A review of machine learning (ML) for spatial prediction of soil contamination.
关键词: Soil contamination Machine learning Prediction Spatial distribution
Optimization of spatial structure designs of control rod using Monte Carlo code RMC
《能源前沿(英文)》 2021年 第15卷 第4期 页码 974-983 doi: 10.1007/s11708-021-0769-5
关键词: control rod optimized spatial structure neutronic performance burnup stability
《环境科学与工程前沿(英文)》 2023年 第17卷 第10期 doi: 10.1007/s11783-023-1722-0
● Nitrifiers in WWTP were investigated at large spatial scale.
关键词: Activated sludge Spatial distributions Microbial assembly Co-occurrence patterns Nitrifying bacteria
Application of cable-supported spatial grid in dry coal shed
XING Haidong, HAO Jiping, XU Guobin
《结构与土木工程前沿(英文)》 2008年 第2卷 第1期 页码 26-29 doi: 10.1007/s11709-008-0008-8
关键词: dry material strength low rational configuration influence
Xuying Ma, Ian Longley, Jennifer Salmond, Jay Gao
《环境科学与工程前沿(英文)》 2020年 第14卷 第3期 doi: 10.1007/s11783-020-1221-5
关键词: LUR Air pollution modelling GIS spatial analysis GDAL/OGR Python Pollutant concentration mapping
Divya Udayan J,HyungSeok KIM,Jee-In KIM
《信息与电子工程前沿(英文)》 2015年 第16卷 第1期 页码 12-27 doi: 10.1631/FITEE.1400141
关键词: Digital reconstruction 3D virtual world 3D spatial components Vision and scene understanding
Quantifying and mapping spatial variability of Shanghai household carbon footprints
Shangguang YANG,Chunlan WANG,Kevin LO,Mark WANG,Lin LIU
《能源前沿(英文)》 2015年 第9卷 第1期 页码 115-124 doi: 10.1007/s11708-015-0348-8
关键词: household carbon emissions spatial variability energy policy Shanghai China
武廷海,张能
《中国工程科学》 2016年 第18卷 第5期 页码 52-59 doi: 10.15302/J-SSCAE-2016.05.008
改善通达性是秦巴山脉地区扶贫开发和实现可持续发展的重要手段。本文根据《国家公路网规划(2013年—2030年)》与《中长期铁路网规划》中确定的高速交通网络,研究秦巴山脉地区及周边城市群地区中心城市的可达性,进而模拟秦巴山脉地区的空间格局。研究发现,随着国家规划高速交通网络的建设,秦巴山脉地区将形成以西安为中心的西安—万州、西安—襄阳、西安—洛阳三条放射型主要城市走廊,以及西安—天水、西安—广元、达州—襄阳—南阳—洛阳三条次要城市走廊。受其城市走廊的影响,秦巴山脉地区将形成以陇南、巴中、十堰、栾川为核心的四个巨型绿野。本文建议,未来的秦巴山脉地区空间规划,在努力发挥秦巴山脉地区对周边城市群地区生态平衡作用的同时,要自觉建立秦巴山脉地区内部的空间秩序,合理安排城市走廊与巨型绿野,实现保护与发展的平衡。
标题 作者 时间 类型 操作
A novel decoupling approach to an integrated optical-fiber proximity sensor for robots
LIU Guixiong, LI Xiani
期刊论文
Soil spatial variability impact on the behavior of a reinforced earth wall
Adam HAMROUNI, Daniel DIAS, Badreddine SBARTAI
期刊论文
Industrial eco-efficiency and its spatial-temporal differentiation in China
Wei YANG, Fengjun JIN, Chengjin WANG, Chen LV
期刊论文
Border-search and jump reduction method for size optimization of spatial truss structures
Babak DIZANGIAN, Mohammad Reza GHASEMI
期刊论文
Abundance, spatial distribution, and physical characteristics of microplastics in stormwater detention
期刊论文
Differences in distributions, assembly mechanisms, and putative interactions of AOB and NOB at a large spatial
期刊论文
Application of cable-supported spatial grid in dry coal shed
XING Haidong, HAO Jiping, XU Guobin
期刊论文
PyLUR: Efficient software for land use regression modeling the spatial distribution of air pollutants
Xuying Ma, Ian Longley, Jennifer Salmond, Jay Gao
期刊论文
Animage-based approach to the reconstruction of ancient architectures by extracting and arranging 3D spatial
Divya Udayan J,HyungSeok KIM,Jee-In KIM
期刊论文
Quantifying and mapping spatial variability of Shanghai household carbon footprints
Shangguang YANG,Chunlan WANG,Kevin LO,Mark WANG,Lin LIU
期刊论文